A topline to die for?

Best in Show at the National Working & Pastoral Breeds Association Show at the Malvern Show Ground in Worcestershire last weekend was Veneze Ellie, owned by John and Pauline Cullen.

Best in Show judge Ferelith Somerfield noted in her critique: "nothing exaggerated".

The 2009-born bitch is a daughter of "the great" Zamp vom Thermados who won the lot before he died prematurely of undisclosed causes (the word, though, is that it was bloat) at the age of eight.

She looks like her dad - as do most of the huge number of Zamp offspring populating the UK show-ring. This includes her half-brother, the top-winning Elmo vom Huhnegrab, owned by the same kennel, who is in great demand as a stud himself. According to the Kennel Club's Mate Select, he has now sired 159 puppies from 29 litters

More info/pix on Ellie here.

Tell me what you see.

Looking at dog brains

Today I was privileged to visit Dr. Greg Berns' laboratory to see awake dogs in an fMRI. In vet school, of course I saw dogs getting MRIs of their brains as part of medical diagnostics, in hunts for cancer, stroke, inflammation, etc. But because an MRI requires that the subject hold perfectly still for several minutes at a time, these dogs were under general anesthesia, which is both expensive for the owner and physically difficult on the dog.

In humans, we can use the related technology, functional MRI (fMRI), to see changes in brain activity in response to different stimuli, such as music, smells, or looking at pictures. This is a useful tool in research, for example as we try to figure out which brain areas perform which tasks. In dogs, we haven't been able to do such studies, because the only way to keep dogs still enough for an fMRI has been to anesthetize them, and obviously a sleeping dog isn't going to have a meaningful reaction to external stimuli.

At Dr. Berns' lab, they have trained dogs to hold still in an fMRI machine while resting their chins on a chin rest. Can your dog hold its head perfectly still for minutes at a time? What about in a strange room, with loud machine noises all around, with ear muffs on to protect their hearing? It's an impressive feat, and done using entirely positive methods. (The training protocol was developed by Mark Spivak of Comprehensive Pet Therapy, Inc.)

I was most impressed by the dogs' relaxed body language. They entered the machine willingly, when their owners asked them to. They lay down with their chins on the rest and waited. As I watched from behind, I could see that many of the dogs were lying on one hip or even frog-legged, in very relaxed postures, suggesting that they were comfortable being in the machine. (Have you ever had an MRI? It is a claustrophobic experience. Humans getting MRIs would benefit from the extensive conditioning preparation that these dogs had, as well as having a loved one present to feed them treats periodically!) Some dogs would balk at some points and exit the machine, at which point their handler would ask them to return and they would. Dogs always had the opportunity to leave. At the end of the test, they came out happy and wriggly.

Highlights of the day for me:

  • The Boston terrier who hurled himself into the fMRI at full speed and then became rock-still for as long as his owner asked him to. That dog was committed to his fMRI experience! (Who would expect the Boston to be the calmest dog in the magnet?)
  • The dogs with their ear protectors wrapped onto their heads with an elastic material normally used to attach catheters and the like. They looked hilarious.
  • The treats fed to dogs on the end of long sticks so that they're easier to deliver inside the magnet. Ingenious.
  • Personally getting to participate in experiments by giving hand signals to dogs who were in the magnet, watching me intently as they waited for their treats.
The joke around the lab is that these tests will tell us why our dogs really love us: are we best friends or just food dispensers? It is a joke because of course fMRI is not a test for love; science has some trouble testing for squishy concepts like that. But fMRI does give us a new  tool for guessing at what goes on in doggy heads, in addition to having to muck around with hormones like cortisol (as I have done) or strange little cognition tests like separation experiments or pointing experiments, as others have done. We have never been able to use this tool on awake animals before, so this is a huge step forward.

It was a fascinating day. I am deeply happy to see non-invasive research going on which takes the welfare of its canine participants into account, and waiting with bated breath to find out the results of the experiments I saw.

Further reading

Health care agents on mobile phones for pets?

I was just listening to a podcast about new health care technology using mobile phones. For example: someone wants to start eating healthier food. They install an agent on their mobile device which checks in with them every few days, asking things like How’s it going? Not so well? Why not? These agents are interactive, so if the user complains that things are not going well, it can understand the answer and reply: Here are some ideas to help you get past that particular hurdle. So I thought: why not for pets?

Imagine that when someone adopts a new dog (from a breeder or a shelter) they are asked if they’re willing to be signed up for a free preventive health care service. When they agree, they give their mobile phone number to the service. The shelter also provides some information about the animal: age, gender, if it is already spayed/neutered, and anything they think might need followup (such as if the animal is not housetrained, or if it is a jumpy-mouthy dog).

A week later, the new adopter gets a text message: How’s it going? Have you made your first vet appointment for Buster yet? No? Would you like some suggestions of veterinarians located near your home?

A few weeks later: How’s Buster? How is housetraining going? Not so well? Would you like some suggestions of dog trainers located in your area? The application might also alert the shelter that there is a training problem, so that the shelter can provide some followup if they have the resources.

And perhaps yearly: How’s Buster? Have you gotten his yearly checkup?

It would make an interesting study: are owners randomized into this service less likely to return their new pets than owners who are randomized out of it? How many owners continue to use the service (and how many request being removed from it)? Do owners find it helpful or annoying?

The first step, I imagine, is for me to do some reading on how these agents are implemented on the human side. I don’t know anything about this particular area, so anyone out there in internet land who has ideas for where to start (specifically, suggestions of peer-reviewed papers), they’d be welcome!

New kid on the blog...

Well this is just fab... a new journal dedicated to canine genetics and epidemiology, with a genuinely unique feature: every piece of new research published by Canine Genetics + Epidemiology (CGE) will be accompanied by an extensive lay summary "so non-scientists can capture key messages for the research."

The new journal is open access which means it's free.. anyone can download and read all the articles, no subscription required.

And the venture is being supported by the Kennel Club Educational Trust, which will fund 50 per cent of the manuscript-processing costs.  This is a great use of the KC charity's funds and I wish it every success.
“I am hugely enthusiastic about the new journal, Canine Genetics and Epidemiology, " says the Animal Health Trust's Cathryn Mellersh who is on the editorial board. "The current field of canine genetics and epidemiology is an extremely dynamic and exciting discipline to be a part of, but it is vitally important that all canine stakeholders, and not just scientists, can access, understand and ultimately implement the findings from all this research. 
"A key, and unique, feature of CGE is its aim to make research findings accessible to veterinarians, dog breeders and owners, as well scientists, and to facilitate this aim each published article will include an extended lay summary plus key “take home messages” for non-specialists and an educated lay readership.  I believe this aim will set CGE apart from other similar journals in the sector, and means CGE will play a central role in disseminating the research riches that the dog provides.”
Joint Editors-in-Chief are Bill Ollier, Professor of Immunogenetics at Manchester Univeristy, and my old foe, Jeff Sampson, former genetics advisor to the Kennel Club. 

Managing Editor is Lorna Kennedy who works alongside Bill Ollier at the University of Manchester with a special interest in the MHC - the area of the genome that codes for immune function.

An international and mostly-impressive editorial board includes many well-known names in canine genetics (and one or two rather notable absences such as Åke Hedhammer and epidemiologist Brenda Bonnett... perhaps just too busy?)


  • Prof Bill Ollier, University of Manchester, UK
  • Prof Jeff Sampson, The Kennel Club, UK

Managing Editor

  • Dr Lorna Kennedy, University of Manchester, UK

Editorial Board

  • Jerold Bell, Tufts University, USA
  • Matthew Breen, North Carolina State University, USA
  • David Brodbelt, Royal Veterinary College, UK
  • Brian Catchpole, Royal Veterinary College, UK
  • Dylan Clements, University of Edinburgh, UK
  • Lluis Ferrer, Tufts University, USA
  • Merete Fredholm, University of Copenhagen, Denmark
  • Francis Galibert, Université de Rennes 1, France
  • Urs Giger, University of Pennsylvania, USA
  • Sergey Knyazev, Novosibirsk State University, Russia
  • Aimee Llewellyn, The Kennel Club, UK
  • Hannes Lohi, University of Helsinki, Finland
  • Cathryn Mellersh, Animal Health Trust, UK
  • Kenton Morgan, University of Liverpool, UK
  • Mark Neff, Van Andel Research Institute, USA
  • Clare Rusbridge, Stone Lion Veterinary Hospital, UK
  • David Sargan, University of Cambridge, UK
  • Peter Savolainen, Royal Institute of Technology, Sweden
  • Jennifer M Seddon, University of Queensland, Australia
  • Robert Shiel, Murdoch University, Australia
  • Andrea Short, University of Manchester, UK
  • Armando Sánchez, Universitat Autònoma de Barcelona, Spain
  • Claire Wade, University of Sydney, Australia
  • Matthew Webster, Uppsala University, Sweden

Can't really think of a single bad thing to say about this and I look forward to reading it.

Hopefully, this journal will become the repository for research that we are still waiting for from the Animal Health Trust/KC - such as the long-promised effective population size data on UK dogs; research that was completed ages ago but has still not been released.  

You can read more about the new journal here where, inexplicably, there is a picture of a rather bemused Labrador surrounded by bubbles. 

You can sign up to receive the journal's articles - for free - here.